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Regina and Margaret DeFrancisco are two sisters who, as teenagers, murdered Regina's boyfriend Oscar Velazquez. They were fugitives until 2002. The two were featured on America's Most Wanted.

The two had fooled Oscar into giving them $1,000, pretending that Regina had gotten locked up and needed bail money. In actuality, the girls used it to further their gang connections. On June 6, 2000, they offered a threesome to pay him back. As Oscar followed Regina into the basement of a friend's house, Margaret shot him in the back of the head. The DeFranciscos and their friend took the body and tried to burn it with nail polish removal.

The two girls were on the run for two years until they were both caught. Regina showed no remorse, except for getting caught.

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